Sp6 downregulation of follistatin gene expression in ameloblasts
نویسندگان
چکیده
منابع مشابه
Dissection of morphological and metabolic differentiation of ameloblasts via ectopic SP6 expression.
Tooth enamel is the hardest organ in the body. In rodent incisor, the enamel is exclusively produced by ameloblasts with yellowish-brown pigmentation, indicating normal enamel formation. However, the molecular mechanisms of ameloblast differentiation and amelogenesis are not fully understood. Specificity protein (Sp) 6 has been reported as one of the critical factors for tooth development. To e...
متن کاملFollistatin-related gene expression, but not follistatin expression, is decreased in human endometrial adenocarcinoma.
OBJECTIVE Activin A is a multifunctional growth and cell differentiation factor produced by normal endometrium, and secreted in high amounts by endometrial adenocarcinoma. In the present study we evaluated the expression of two inhibitory activin A ligands, follistatin and follistatin-related gene (FLRG), in endometrial adenocarcinoma and in age-matched healthy human endometrium. DESIGN AND M...
متن کاملP9-reduced expression of tight junction proteins ZO-1 and Claudin-1 in ameloblasts and odontoblasts of Epiprofin/Sp6 deficient mice.
Introduction Odontoblasts and ameloblasts are columnar cells that characterize by a highly polarized distribution of organelles. Junctional complexes and the cytoskeleton are important in maintaining ameloblast and odontoblast cell polarity and cell-cell interactions. In addition, cell adhesion is a key regulator of gene expression and cell differentiation. Tight junction binding proteins prote...
متن کاملNucleotide sequence and expression of the cloned gene of bacteriophage SP6 RNA polymerase.
The coding region of the gene for bacteriophage SP6 RNA polymerase was cloned into pBR322, and its entire nucleotide sequence was deduced. The predicted amino acid sequence for the polymerase consists of 874 amino acid residues with a total molecular weight of 98,561 daltons. Comparison of the amino acid sequence with that of T7 RNA polymerase reveals that regions with partial homology are pres...
متن کاملExpression of the sodium/calcium/potassium exchanger, NCKX4, in ameloblasts.
Transcellular calcium transport is an essential activity in mineralized tissue formation, including dental hard tissues. In many organ systems, this activity is regulated by membrane-bound sodium/calcium (Na(+)/Ca(2+)) exchangers, which include the NCX and NCKX [sodium/calcium-potassium (Na(+)/Ca(2+)-K(+)) exchanger] proteins. During enamel maturation, when crystals expand in thickness, Ca(2+) ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Medical Investigation
سال: 2008
ISSN: 1343-1420,1349-6867
DOI: 10.2152/jmi.55.87